This chapter presents the analysis of the molecular mechanism of action of salicylates with the aim of interpreting the therapeutic effects of these drugs in terms of their interactions with biochemical processes in cells or tissues. https://doi.org/10.1016/S1054-3589(08)60012-5. Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. However, extensive research shows the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). The primary task, however, was to identify the biochemical process or processes whose modification by salicylates led to the therapeutic effects of these drugs and to examine how these effects occurred. Such binding might be expected to occur—for example, at the active site of an enzyme, at the receptor for a neurohumoral transmitter, or at some comparable point. N-ethylethanamine;2-hydroxybenzoic acid. Chemical Name. 211. Diethylamine 2-hydroxybenzoate. Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. Lees P, Landoni MF, Giraudel J, Toutain PL. | Clipboard, Search History, and several other advanced features are temporarily unavailable. Literature retrieval was performed through PubMed/MEDLINE (through May 2009) using combinations of the terms diclofenac, NSAID, mechanism of action, COX-1, COX-2, and pharmacology. It produces reddening of the skin by dilatation of the blood vessel and gives a soothing feeling of warmth. Dansom Lane. We use cookies to help provide and enhance our service and tailor content and ads. Eucalyptus Globulus protects against diclofenac sodium induced hepatorenal and testicular toxicity in male rats. It works by first cooling the skin then warming it up, providing a topical anesthetic and analgesic action on the affected area. 3 … J Tradit Complement Med. eCollection 2020. The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs). Inhibition of the cyclooxygenase of prostaglandin synthetase explains those actions of salicylates in which aspirin is more potent than sodium salicylate, including certain forms of analgesia, inhibition of platelet aggregation, antagonism of bradykinin-induced bronchoconstriction in the guinea pig, and possibly antipyresis. This article reviews the established, putative, and emerging MOAs of diclofenac; compares the drug's pharmacologic and pharmacodynamic properties with other NSAIDs to delineate its potentially unique qualities; hypothesizes why it has been chosen for further recent formulation enhancement; and evaluates the potential effect of its MOA characteristics on safety. Non-steroidal anti-inflammatory drug, NSAID. Front Psychiatry. More... Molecular Weight: 211.26 g/mol. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Get the latest research from NIH: https://www.nih.gov/coronavirus. USA.gov. Therapeutic Categories. Diethylamine Salicylate: Please discuss the risks and benefits with your doctor. Contents. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Discussion: Commentary: Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders. Diethylamine Salicylate generic Diethylamine salicylate has painkilling and anti-inflammatory properties. Reckitt & Colman Pharmaceutical Division. 4419-92-5. EXPOSURE: Workers that produce or use diethylamine may breathe in mists or have direct skin contact. eCollection 2020 Nov. Front Immunol. As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. J Vet Pharmacol Ther. This task was pursued along two main lines, emerging from the questions: (1) what is the character of the therapeutic actions of salicylates and (2) what potent effect(s) of salicylates at a molecular level might give rise to actions of this character? Copyright © 2020 Elsevier B.V. or its licensors or contributors. Research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide-cGMP antinociceptive pathway. Background: By continuing you agree to the use of cookies. Additionally, as the highlighted putative and emerging MOAs do not have clinical data to demonstrate that these models are correct, further research is necessary to ascertain if the proposed pathways will translate into clinical benefits. It also acts as an antacid. England. 2 Names and Identifiers Expand this section. 1 Structures Expand this section. 2004 Dec;27(6):479-90. doi: 10.1111/j.1365-2885.2004.00617.x. The primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of the transiently expressed prostaglandin-endoperoxide synthase-2 (PGES-2) also known as cycloxygenase-2 (COX-2). Acta Anaesthesiol Scand Suppl. Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Falgueyret JP, Ford-Hutchinson AW, Gordon R, Greig G, Gresser M, Guay J, Kargman S, Léger S, Mancini JA, O'Neill G, Ouellet M, Rodger IW, Thérien M, Wang Z, Webb JK, Wong E, Chan CC, et al. Bismuth subsalicylate is available without a … Objective To determine the efficacy and safety of topical rubefacients containing salicylates in acute and chronic pain. Mechanism of Action of Diethylamine salicylate Diethylamine salicylate is a rubefacient. Is There a Role for Statins and COX-2 Inhibitors in the Prevention and Early Treatment of the Disease? Diethylamine Salicylate CAS registry number (Chemical Abstracts Service) 0004419-92-5. It is expected that such interactions might result from the binding of the drug molecule with one or more types of macromolecule that conducts such processes. It is also called as counterirritant because they produce their action by counter irritation. Fecker LF, Stockfleth E, Nindl I, Ulrich C, Forschner T, Eberle J. Br J Dermatol.